In our recent rearch, we use traditional Chineses medicine prescription-Yiqihuoxue formula treating SSc patients. The result showed:  Yiqihuoxue treatment could effectively reduce collagen production via down-regulating the phosphorylation
of Smad3 and then the activity of SBE, which are involved in the TGF-β pathway and constitutively activated in the
progression of SSc. The result has been published in BMC Complementary and Alternative Medicine 2014, 14:224
http://www.biomedcentral.com/1472-6882/14/224